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Article

Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jan 2006

Zhang Ren, Murakami Shunichi, Coustry Françoise, Wang Ying, de Crombrugghe Benoit

Abstract excerpt

Accumulating in vitro evidence suggests that the p38 mitogen-activated protein kinase (MAPK) pathway is involved in endochondral ossification. To investigate the role of this pathway in endochondral ossification, we generated transgenic mice with expression in chondrocytes of a constitutively active mutant of MKK6, a MAPK kinase that specifically activates p38. These mice had a dwarf phenotype characterized by...

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Source

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Identifiers

PMID: 16387856
DOI: 10.1073/pnas.0507979103
PMCID: PMC1326166

Genes

PTH
SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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