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Article

Mitogen-activated protein kinase p38 induces HDAC4 degradation in hypertrophic chondrocytes.

Biochimica et biophysica acta - 1 Feb 2015

Zhou Jingming, Li Pengcui, Chen Qian, Wei Xiaochun, Zhao Ting, Wang Zhengke, Wei Lei

Abstract excerpt

Histone deacetylase 4 (HDAC4) is a critical negative regulator for chondrocyte hypertrophy by binding to and inhibiting Runx2, a critical transcription factor for chondrocyte hypertrophy. It is unclear how HDAC4 expression and stability are regulated during growth plate development. We report here that inhibition of mitogen-activated protein kinase (MAPK) p38 by dominant negative p38 or p38 inhibitor prevents...

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Source

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Identifiers

PMID: 25447540
DOI: 10.1016/j.bbamcr.2014.11.003
PMCID: PMC4289442

Genes

HDAC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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