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Article

Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development.

The Journal of cell biology - 26 Feb 2007

Ge Chunxi, Xiao Guozhi, Jiang Di, Franceschi Renny T

Abstract excerpt

The extracellular signal-regulated kinase (ERK)-mitogen-activated protein kinase (MAPK) pathway provides a major link between the cell surface and nucleus to control proliferation and differentiation. However, its in vivo role in skeletal development is unknown. A transgenic approach was used to establish a role for this pathway in bone. MAPK stimulation achieved by selective expression of constitutively active...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17325210
DOI: 10.1083/jcb.200610046
PMCID: PMC2064027

Genes

RUNX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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