Article
Systematic review and meta-analysis of the moderating effect of rs1799971 in OPRM1, the mu-opioid receptor gene, on response to naltrexone treatment of alcohol use disorder.
Addiction (Abingdon, England) - 1 Aug 2020
Hartwell Emily E, Feinn Richard, Morris Paige E, Gelernter Joel, Krystal John, Arias Albert J, Hoffman Michaela, Petrakis Ismene, Gueorguieva Ralitza, Schacht Joseph P, Oslin David, Anton Raymond F, Kranzler Henry R
Abstract excerpt
BACKGROUND AND AIMS: There is wide inter-individual variability in response to the treatment of alcohol use disorder (AUD) with the opioid receptor antagonist naltrexone. To identify patients who may be most responsive to naltrexone treatment, studies have examined the moderating effect of rs1799971, a single nucleotide polymorphism (SNP) that encodes a non-synonymous substitution (Asn40Asp) in the mu-opioid...
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