Waiting times for the appearance of cytotoxic T-lymphocyte escape mutants in chronic HIV-1 infection.

Abstract excerpt

The failure of HIV-1 to escape at some cytotoxic T-lymphocyte (CTL) epitopes has generally been explained in terms of viral fitness costs or ineffective or attenuated CTL responses. Relatively little attention has been paid to the evolutionary time required for escape mutants to be detected. This time is significantly affected by selection, mutation rates, the presence of other advantageous mutations, and the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to HIV-1
• Share to HIV Infections
• Share to Models, Genetic