Article
Impaired immune evasion in HIV through intracellular delays and multiple infection of cells.
Proceedings. Biological sciences - 7 Aug 2012
Althaus Christian L, De Boer Rob J
Abstract excerpt
With its high mutation rate, HIV is capable of escape from recognition, suppression and/or killing by CD8(+) cytotoxic T lymphocytes (CTLs). The rate at which escape variants replace each other can give insights into the selective pressure imposed by single CTL clones. We investigate the effects of specific characteristics of the HIV life cycle on the dynamics of immune escape. First, it has been found that cells...
Topics
- Biological Evolution
- HIV Infections
- HIV-1
- Humans
- Immune Evasion
- Models, Biological
- Mutation
- T-Lymphocytes, Cytotoxic
- Time Factors