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Article

Early-onset ankylosing spondylitis is associated with a functional MICA polymorphism.

Human immunology - 1 Oct 2005

Amroun Habiba, Djoudi Hachemi, Busson Marc, Allat Rachida, El Sherbini Shérif Mohsen, Sloma Ivan, Ramasawmy Rajendranath, Brun Manuel, Dulphy Nicolas, Krishnamoorthy Rajagopal, Toubert Antoine, Charron Dominique, Abbadi Mohamed Chérif, Tamouza Ryad

Abstract excerpt

Major histocompatibility complex (MHC) class I chain-related A (MICA) molecules deliver activating signals through the NKG2D receptor expressed on the surface of natural killer (NK), CD8alphabeta and gammadelta T cells, and the MICA gene is polymorphic. The recently described MICA amino acid substitution at position 129 (MICA-129) seems to affect its binding to NKG2D. We investigated whether this dimorphism...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16386647
DOI: 10.1016/j.humimm.2005.09.004

Genes

MICA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Early-onset ankylosing spondylitis is associated with a functional MICA polymorphism.PMID 16386647Read ↗

Impact of the MICA-129Met/Val Dimorphism on NKG2D-Mediated Biological Functions and Disease RisksSemantic proximity Read ↗

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MICA and NKG2D variants as risk factors in spondyloarthritis: a case-control study.Semantic proximity Read ↗

Association of major histocompatibility complex class 1 chain-related gene a dimorphism with type 1 diabetes and latent autoimmune diabetes in adults in the Algerian population.Semantic proximity Read ↗

Identification of previously unrecognized predisposing factors for ankylosing spondylitis from analysis of HLA-B27 extended haplotypes in Sardinia.Semantic proximity Read ↗

Association of MICA-129 polymorphism with nasopharyngeal cancer risk in a Tunisian population.Semantic proximity Read ↗

The functional MICA-129 polymorphism is associated with skin but not joint manifestations of psoriatic disease independently of HLA-B and HLA-C.Semantic proximity Read ↗

MICA-129Met/Val Polymorphism Is Associated with Early-Onset Breast Cancer Risk.Semantic proximity Read ↗

Polymorphisms of KIRs gene and HLA-C alleles in patients with ankylosing spondylitis: possible association with susceptibility to the disease.Semantic proximity Read ↗

The MICA‐129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantationSemantic proximity Read ↗

Association of MICA-129Met/Val polymorphism with clinical outcome of anti-TNF therapy and MICA serum levels in patients with rheumatoid arthritis.Semantic proximity Read ↗

Role of the MICA polymorphism in systemic lupus erythematosus.Semantic proximity Read ↗

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