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Article

The MICA‐129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantation

19 Oct 2015

Abstract excerpt

The MHC class I chain‐related molecule A (MICA) is a highly polymorphic ligand for the activating natural killer (NK)‐cell receptor NKG2D. A single nucleotide polymorphism causes a valine to methionine exchange at position 129. Presence of a MICA‐129Met allele in patients (n = 452) undergoing hematopoietic stem cell transplantation (HSCT) increased the chance of overall survival (hazard ratio [HR] = 0.77, P =...

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PMID: 26483398
DOI: 10.15252/emmm.201505246

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