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Article

MICA and NKG2D variants as risk factors in spondyloarthritis: a case-control study.

Genes and immunity - 1 Sept 2019

Fechtenbaum Marie, Desoutter Judith, Delvallez Gauthier, Brochot Etienne, Guillaume Nicolas, Goëb Vincent

Abstract excerpt

The major histocompatibility complex class I polypeptide-related sequence A (MICA) glycoprotein mediates the activation of the natural killer group 2D receptor (NKG2D) expressed on NK and CD8+ T cells. A methionine or valine at position 129 in exon 3 results in strong (MICA129 met) or weak (MICA129 val) binding to NKG2D. The MICA A5.1 allele causes a premature stop codon. Various NKG2D polymorphisms are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

Share to Killer Cells, Natural

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Source

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Identifiers

PMID: 30177859
DOI: 10.1038/s41435-018-0044-x
PMCID: PMC6768283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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MICA and NKG2D variants as risk factors in spondyloarthritis: a case-control study.PMID 30177859Read ↗

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