Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of MICA-129 polymorphism with nasopharyngeal cancer risk in a Tunisian population.

Human immunology - 1 Jan 2009

Douik Hayet, Ben Chaaben Arij, Attia Romdhane Neila, Romdhane Habiba Ben, Mamoghli Tesnim, Fortier Catherine, Boukouaci Wahid, Harzallah Latifa, Ghanem Abderraouf, Gritli Said, Makni Mohamed, Charron Dominique, Krishnamoorthy Rajagopal, Guemira Fethi, Tamouza Ryad

Abstract excerpt

Major histocompatibility complex (MHC) class I chain-related A (MICA) molecules mediate natural killer (NK) cell activation and T lymphocyte co-stimulation. A polymorphic methionine (met) to valine (val) variation at amino acid position 129 of the alpha2 heavy chain domain is in linkage disequilibrium with other allelic changes and seems to categorize MICA alleles into strong and weak binder of NKG2D receptor and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

Share to Linkage Disequilibrium

Share to Nasopharyngeal Neoplasms

Share to NK Cell Lectin-Like Receptor Subfamily K

Share to Tunisia

Source

Identifiers

PMID: 19000729
DOI: 10.1016/j.humimm.2008.10.008

Genes

MICA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of MICA-129 polymorphism with nasopharyngeal cancer risk in a Tunisian population.PMID 19000729Read ↗

MICA-129Met/Val Polymorphism Is Associated with Early-Onset Breast Cancer Risk.Semantic proximity Read ↗

MICA-129 Met/Val polymorphism could be a genetic biomarker for Familial Breast Cancer in the Tunisian population.Semantic proximity Read ↗

Impact of the MICA-129Met/Val Dimorphism on NKG2D-Mediated Biological Functions and Disease RisksSemantic proximity Read ↗

MICA-129 Dimorphism and Soluble MICA Are Associated With the Progression of Multiple Myeloma.Semantic proximity Read ↗

Association analysis of MICA gene polymorphism and MICA-129 dimorphism with inflammatory bowel disease susceptibility in a Spanish population.Semantic proximity Read ↗

Early-onset ankylosing spondylitis is associated with a functional MICA polymorphism.Semantic proximity Read ↗

Genetic variants in NKG2D axis and susceptibility to Epstein-Barr virus-induced nasopharyngeal carcinoma.Semantic proximity Read ↗

Association of HLA-G polymorphisms with nasopharyngeal carcinoma risk and clinical outcome.Semantic proximity Read ↗

The MICA-129Met/Val dimorphism affects plasma membrane expression and shedding of the NKG2D ligand MICA.Semantic proximity Read ↗

The MICA‐129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantationSemantic proximity Read ↗

MICA and NKG2D variants as risk factors in spondyloarthritis: a case-control study.Semantic proximity Read ↗

Associations between HLA class I alleles and the prevalence of nasopharyngeal carcinoma (NPC) among Tunisians.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.