Association of MICA-129Met/Val polymorphism with clinical outcome of anti-TNF therapy and MICA serum levels in patients with rheumatoid arthritis.

doi:10.1038/s41397-020-0164-3

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Article

Association of MICA-129Met/Val polymorphism with clinical outcome of anti-TNF therapy and MICA serum levels in patients with rheumatoid arthritis.

The pharmacogenomics journal - 1 Dec 2020

Iwaszko Milena, Świerkot Jerzy, Dratwa Marta, Wysoczańska Barbara, Korman Lucyna, Bugaj Bartosz, Kolossa Katarzyna, Jeka Sławomir, Wiland Piotr, Bogunia-Kubik Katarzyna

Abstract excerpt

MHC class I polypeptide-related sequence A (MICA) is a stress-induced protein involved in activation of NK and T cells through interaction with NKG2D receptor. These molecules are atypically expressed in synovium of patients diagnosed with rheumatoid arthritis (RA). A total of 279 patients with RA, qualified to TNF-blockade therapy, were genotyped for MICA rs1051792 SNP. The effectiveness of anti-TNF agents was...

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PMID: 32123296
DOI: 10.1038/s41397-020-0164-3
PMCID: PMC7674153

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