Article
Circulating hematopoietic progenitors with T lineage potential.
Nature immunology - 1 Sept 2004
Schwarz Benjamin A, Bhandoola Avinash
Abstract excerpt
The thymus is seeded via the blood, but the identity of hematopoietic progenitors with access to the circulation in adult mice is unknown. We report here that the only progenitors in blood with efficient T lineage potential were lineage negative with high expression of stem cell antigen 1 and c-Kit (LSK cells). The blood LSK population, like its counterpart in the bone marrow, contained hematopoietic stem cells...
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