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Article

Tissue-specific inactivation of murine M6P/IGF2R.

The American journal of pathology - 1 Jan 2003

Wylie Andrew A, Pulford David J, McVie-Wylie Alison J, Waterland Robert A, Evans Heather K, Chen Yuan-Tsong, Nolan Catherine M, Orton Terry C, Jirtle Randy L

Abstract excerpt

The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) encodes a multifunctional protein involved in lysosomal enzyme trafficking, fetal organogenesis, tumor suppression, and T cell- mediated immunity. M6P/IGF2R is an imprinted gene in mice with expression only from the maternal allele. Complete knockout of this gene causes neonatal lethality, thus preventing analysis of its multifunctional...

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Identifiers

PMID: 12507915
DOI: 10.1016/S0002-9440(10)63823-0
PMCID: PMC1851115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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