Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tracking the Cartoon mouse phenotype: Hemopexin domain-dependent regulation of MT1-MMP pericellular collagenolytic activity.

The Journal of biological chemistry - 25 May 2018

Sakr Moustafa, Li Xiao-Yan, Sabeh Farideh, Feinberg Tamar Y, Tesmer John J G, Tang Yi, Weiss Stephen J

Abstract excerpt

Following ENU mutagenesis, a phenodeviant line was generated, termed the "Cartoon mouse," that exhibits profound defects in growth and development. Cartoon mice harbor a single S466P point mutation in the MT1-MMP hemopexin domain, a 200-amino acid segment that is thought to play a critical role in regulating MT1-MMP collagenolytic activity. Herein, we demonstrate that the MT1-MMPS466P mutation replicates the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Membrane
Share to Collagen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crystallography, X-Ray

Share to Extracellular Matrix

Share to Matrix Metalloproteinase 14

Share to Mice, Inbred C57BL

Share to Mice, Knockout

Share to Protein Transport

Source

Open in PubMed Open full text

Identifiers

PMID: 29643184
DOI: 10.1074/jbc.RA117.001503
PMCID: PMC5971454

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tracking the Cartoon mouse phenotype: Hemopexin domain-dependent regulation of MT1-MMP pericellular collagenolytic activity.PMID 29643184Read ↗

MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen TurnoverSemantic proximity Read ↗

Mouse Models of Human Proprotein Convertase InsufficiencySemantic proximity Read ↗

Models for gain-of-function and loss-of-function of MMPs. Transgenic and gene targeted mice.Semantic proximity Read ↗

Targeted truncation of the ADAM17 cytoplasmic domain in mice results in protein destabilization and a hypomorphic phenotype.Semantic proximity Read ↗

Matriptase drives early-onset intestinal failure in a mouse model of congenital tufting enteropathySemantic proximity Read ↗

Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway.Semantic proximity Read ↗

Tropoelastin heterogeneity: implications for protein function and disease.Semantic proximity Read ↗

Mammalian skeletogenesis and extracellular matrix: what can we learn from knockout mice?Semantic proximity Read ↗

[Origin of the diversity and similarity of pathological manifestations of collagen disease: lessons from murine models in an aspect of pathogenomics].Semantic proximity Read ↗

Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice.Semantic proximity Read ↗

Unraveling metalloproteinase function in skeletal biology and disease using genetically altered miceSemantic proximity Read ↗

Two functional forms of the Meckel-Gruber syndrome protein TMEM67 generated by proteolytic cleavage by ADAMTS9 mediate Wnt signaling and ciliogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.