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Article

Knock-out mouse models of proprotein convertases: unique functions or redundancy?

Frontiers in bioscience : a journal and virtual library - 1 May 2008

Creemers John W M, Khatib Abdel-Majid

Abstract excerpt

The members of the proprotein convertase family play a central role in the processing and/or activation of various protein precursors involved in many physiological processes and various pathologies. The proteolysis of these precursors that occur at basic residues within the general motif (K/R)-(X)-(K/R) is mediated by the proprotein convertases PC1/3, PC2, Furin, PACE4, PC4, PC5 and PC7, whereas the proteolysis...

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Source

Identifiers

PMID: 18508561
DOI: 10.2741/3055

Genes

PCSK9
SKI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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