Article
Altered RNA editing in mice lacking ADAR2 autoregulation.
Molecular and cellular biology - 1 Jan 2006
Feng Yi, Sansam Christopher L, Singh Minati, Emeson Ronald B
Abstract excerpt
ADAR2 is a double-stranded-RNA-specific adenosine deaminase involved in the editing of mammalian RNAs by the site-selective conversion of adenosine to inosine. Previous studies from our laboratory have demonstrated that ADAR2 can modify its own pre-mRNA to create a proximal 3' splice site containing a noncanonical adenosine-inosine dinucleotide. Alternative splicing to this proximal acceptor adds 47 nucleotides...
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