Article
A comparative analysis of ADAR mutant mice reveals site-specific regulation of RNA editing.
RNA (New York, N.Y.) - 1 Apr 2020
Costa Cruz Pedro Henrique, Kato Yuki, Nakahama Taisuke, Shibuya Toshiharu, Kawahara Yukio
Abstract excerpt
Adenosine-to-inosine RNA editing is an essential post-transcriptional modification catalyzed by adenosine deaminase acting on RNA (ADAR)1 and ADAR2 in mammals. For numerous sites in coding sequences (CDS) and microRNAs, editing is highly conserved and has significant biological consequences, for example, by altering amino acid residues and target recognition. However, no comprehensive and quantitative studies...
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