Mouse models for understanding physiological functions of ADARs.

Abstract excerpt

Adenosine-to-inosine (A-to-I) editing, is a highly prevalent posttranscriptional modification of RNA, mediated by the adenosine deaminases acting on RNA (ADAR) proteins. Mammalian transcriptomes contain tens of thousands to millions of A-to-I editing events. Mutations in ADAR can result in rare autoinflammatory disorders such as Aicardi-Goutières syndrome (AGS) through to irreversible conditions such as motor...

Topics

• Animals
• Adenosine Deaminase
• Mice
• Humans
• Disease Models, Animal
• RNA Editing
• Adenosine
• Autoimmune Diseases of the Nervous System