Article
Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis.
Experimental hematology - 1 Oct 2016
Liddicoat Brian J, Hartner Jochen C, Piskol Robert, Ramaswami Gokul, Chalk Alistair M, Kingsley Paul D, Sankaran Vijay G, Wall Meaghan, Purton Louise E, Seeburg Peter H, Palis James, Orkin Stuart H, Lu Jun, Li Jin Billy, Walkley Carl R
Abstract excerpt
Adenosine deaminases that act on RNA (ADARs) convert adenosine residues to inosine in double-stranded RNA. In vivo, ADAR1 is essential for the maintenance of hematopoietic stem/progenitors. Whether other hematopoietic cell types also require ADAR1 has not been assessed. Using erythroid- and myeloid-restricted deletion of Adar1, we demonstrate that ADAR1 is dispensable for myelopoiesis but is essential for normal...
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