Article
Primary chemoprevention of familial adenomatous polyposis with sulindac.
The New England journal of medicine - 4 Apr 2002
Giardiello Francis M, Yang Vincent W, Hylind Linda M, Krush Anne J, Petersen Gloria M, Trimbath Jill D, Piantadosi Steven, Garrett Elizabeth, Geiman Deborah E, Hubbard Walter, Offerhaus G Johan A, Hamilton Stanley R
Abstract excerpt
BACKGROUND: Familial adenomatous polyposis is caused by a germ-line mutation in the adenomatous polyposis coli gene and is characterized by the development of hundreds of colorectal adenomas and, eventually, colorectal cancer. Nonsteroidal antiinflammatory drugs can cause regression of adenomas, but whether they can prevent adenomas is unknown. METHODS: We conducted a randomized, double-blind, placebo-controlled...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.