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Article

Statin Treatment as a Targeted Therapy for APC-Mutated Colorectal Cancer

30 May 2022

Abstract excerpt

Background Mutations in the tumor suppressor gene Adenomatous Polyposis Coli (APC) are found in 80% of sporadic colorectal cancer (CRC) tumors and are also responsible for the inherited form of CRC, Familial adenomatous polyposis (FAP). Methods To identify novel therapeutic strategies for the treatment of APC mutated CRC, we generated a drug screening platform that incorporates a human cellular model of APC...

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PMID: 35712511
DOI: 10.3389/fonc.2022.880552

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