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Fluorinated <i>N</i>,<i>N</i>-Dialkylaminostilbenes for Wnt Pathway Inhibition and Colon Cancer Repression

3 Feb 2011

Abstract excerpt

Colorectal cancer (CRC) is the second leading cause of cancer-related mortality in the United States. CRC is initiated by mutations of the tumor suppressor gene, adenomatous polyposis coli (APC), or β-catenin gene. These mutations stabilize β-catenin and constitutively activate Wnt/β-catenin target genes, such as c-Myc and cyclin D1, ultimately leading to cancer. Naturally occurring stilbene derivatives,...

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PMID: 21291235
DOI: 10.1021/jm101248v

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