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Article

Point mutations upstream of hepatitis B virus core gene affect DNA replication at the step of core protein expression.

Journal of virology - 1 Jan 2006

Guarnieri Michael, Kim Kyun-Hwan, Bang Genie, Li Jisu, Zhou Yonghong, Tang Xiaoli, Wands Jack, Tong Shuping

Abstract excerpt

The pregenomic RNA directs replication of the hepatitis B virus (HBV) genome by serving both as the messenger for core protein and polymerase and as the genome precursor following its packaging into the core particle. RNA packaging is mediated by a stem-loop structure present at its 5' end designated the epsilon signal, which includes the core gene initiator AUG. The precore RNA has a slightly extended 5' end to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16378961
DOI: 10.1128/JVI.80.2.587-595.2006
PMCID: PMC1346833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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