Naturally occurring missense mutation in the polymerase gene terminating hepatitis B virus replication.

Abstract excerpt

A hepatitis B virus (HBV) genome was cloned from human liver. Numerous mutations in all viral genes define this HBV DNA as a mutant, divergent from all known HBV DNA sequences. Functional analyses of this mutant demonstrated a defect blocking viral DNA synthesis. The genetic basis of this defect was identified as a single missense mutation in the 5' region of the viral polymerase gene, resulting in the inability...

Topics

• Base Sequence
• DNA, Viral
• DNA-Directed DNA Polymerase
• Gene Expression
• Genes, Viral
• Genetic Complementation Test
• Hepatitis B virus
• Molecular Sequence Data
• Mutation
• RNA, Viral
• Virus Replication