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Article

Naturally occurring missense mutation in the polymerase gene terminating hepatitis B virus replication.

Journal of virology - 1 Apr 1991

Blum H E, Galun E, Liang T J, von Weizsäcker F, Wands J R

Abstract excerpt

A hepatitis B virus (HBV) genome was cloned from human liver. Numerous mutations in all viral genes define this HBV DNA as a mutant, divergent from all known HBV DNA sequences. Functional analyses of this mutant demonstrated a defect blocking viral DNA synthesis. The genetic basis of this defect was identified as a single missense mutation in the 5' region of the viral polymerase gene, resulting in the inability...

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Identifiers

PMID: 2002544
DOI: 10.1128/JVI.65.4.1836-1842.1991
PMCID: PMC239993

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