Article
Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal.
Proceedings of the National Academy of Sciences of the United States of America - 26 Apr 1994
Lok A S, Akarca U, Greene S
Abstract excerpt
We conducted a large-scale survey to determine the frequency and clinical significance of mutations in the pre-core region of hepatitis B virus (HBV). Sera from 263 patients with chronic HBV infection were analyzed by direct sequencing of PCR-amplified HBV DNA. Four major missense/nonsense mutati...
Topics
- Base Sequence
- DNA Primers
- DNA, Viral
- Genes, Viral
- Hepatitis B
- Hepatitis B Core Antigens
- Hepatitis B e Antigens
- Hepatitis B virus
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Viral Structural Proteins
- Virus Replication