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Article

Hepatitis B virus nucleocapsids formed by carboxy-terminally mutated core proteins contain spliced viral genomes but lack full-size DNA.

Journal of virology - 1 Dec 2004

Köck Josef, Nassal Michael, Deres Karl, Blum Hubert E, von Weizsäcker Fritz

Abstract excerpt

The carboxy-terminal sequence of the hepatitis B virus (HBV) core protein constitutes a nucleic acid binding domain that is rich in arginine residues and contains three serine phosphorylation sites. While dispensable for capsid assembly, this domain is involved in viral replication, as demonstrated by the effects of mutations on RNA packaging and/or reverse transcription; however, the underlying mechanisms are...

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Identifiers

PMID: 15564489
DOI: 10.1128/JVI.78.24.13812-13818.2004
PMCID: PMC533894

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Source receipt: pubmed, retrieved 7 Sept 2026.

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