Article
Protein- and RNA-synthesis independent bactericidal activity of ciprofloxacin that involves the A subunit of DNA gyrase.
Journal of medical microbiology - 1 Jan 1991
Lewin C S, Howard B M, Smith J T
Abstract excerpt
Ciprofloxacin, unlike nalidixic acid, can kill Escherichia coli cells in the absence of synthesis of protein or RNA. Hence, chloramphenicol or rifampicin do not abolish the bactericidal activity of ciprofloxacin against wild-type E. coli. Protein and RNA synthesis were not required for the bactericidal activity of ciprofloxacin against nalB, nalC and nalD mutants of E. coli. However, the addition of...
Topics
- Cell Membrane Permeability
- Chloramphenicol Resistance
- Ciprofloxacin
- DNA Topoisomerases, Type II
- Escherichia coli
- Microbial Sensitivity Tests
- Mutation
- Nalidixic Acid
- RNA, Bacterial
- Rifampin