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Article

Lon protease is essential for paradoxical survival of Escherichia coli exposed to high concentrations of quinolone.

Antimicrobial agents and chemotherapy - 1 Jul 2009

Malik Muhammad, Capecci Joseph, Drlica Karl

Abstract excerpt

A deficiency of the Escherichia coli Lon protease blocked paradoxical survival occurring at very high nalidixic acid concentrations. The absence of Lon also blocked a parallel increase in cell lysate viscosity likely to reflect DNA size. Thus, Lon may participate in repairing quinolone-mediated DNA lesions formed at high drug concentrations.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19414573
DOI: 10.1128/AAC.00019-09
PMCID: PMC2704693

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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