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Article

Increase in synthesis and stability of sigma 32 on treatment with inhibitors of DNA gyrase in Escherichia coli.

Molecular & general genetics : MGG - 13 Dec 1996

Mizushima T, Ohtsuka Y, Mori H, Miki T, Sekimizu K

Abstract excerpt

We report here that in Escherichia coli, the anti-bacterial agent nalidixic acid induces transient stabilization and increased synthesis of sigma 32, accompanied by the induction of heat shock proteins (Dnak and GroEL proteins). The induction of heat shock proteins, increased synthesis of sigma 32, and stabilization of sigma 32 observed on treatment of wild-type cells with nalidixic acid were not observed in a...

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Identifiers

PMID: 9003316
DOI: 10.1007/pl00008596

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Increase in synthesis and stability of sigma 32 on treatment with inhibitors of DNA gyrase in Escherichia coli.PMID 9003316Read ↗

Induction of heat shock proteins by abnormal proteins results from stabilization and not increased synthesis of sigma 32 in Escherichia coli.Semantic proximity Read ↗

Conserved region 2.1 of Escherichia coli heat shock transcription factor sigma32 is required for modulating both metabolic stability and transcriptional activity.Semantic proximity Read ↗

DnaK, DnaJ, and GrpE heat shock proteins negatively regulate heat shock gene expression by controlling the synthesis and stability of sigma 32.Semantic proximity Read ↗

Transient DNA relaxation in Escherichia coli induced by nalidixic acid.Semantic proximity Read ↗

Effect of anaerobic and stationary phase growth conditions on the heat shock and oxidative stress responses in Escherichia coli K-12.Semantic proximity Read ↗

Evidence for an active role of the DnaK chaperone system in the degradation of sigma(32).Semantic proximity Read ↗

Identification of a turnover element in region 2.1 of Escherichia coli sigma32 by a bacterial one-hybrid approach.Semantic proximity Read ↗

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