Increase in synthesis and stability of sigma 32 on treatment with inhibitors of DNA gyrase in Escherichia coli.

doi:10.1007/pl00008596

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Article

Increase in synthesis and stability of sigma 32 on treatment with inhibitors of DNA gyrase in Escherichia coli.

Molecular & general genetics : MGG - 13 Dec 1996

Mizushima T, Ohtsuka Y, Mori H, Miki T, Sekimizu K

Abstract excerpt

We report here that in Escherichia coli, the anti-bacterial agent nalidixic acid induces transient stabilization and increased synthesis of sigma 32, accompanied by the induction of heat shock proteins (Dnak and GroEL proteins). The induction of heat shock proteins, increased synthesis of sigma 3...

Topics

Anti-Infective Agents
Bacterial Proteins
DNA Topoisomerases, Type II
Enzyme Inhibitors
Escherichia coli
Heat-Shock Proteins
Mutation
Nalidixic Acid
Novobiocin
Oxolinic Acid
Sigma Factor
Topoisomerase II Inhibitors
Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 9003316
DOI: 10.1007/pl00008596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9003316-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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