Article
Cell-type-specific pathways of neurotensin endocytosis.
Cell and tissue research - 1 Apr 2006
Savdie Cheryl, Ferguson Stephen S G, Vincent J- P, Beaudet Alain, Stroh Thomas
Abstract excerpt
The neurotensin receptor subtype 1 (NTS1) is a G-protein-coupled receptor (GPCR) mediating a large number of central and peripheral effects of neurotensin. Upon stimulation, NTS1 is rapidly internalized and targeted to lysosomes. This process depends on the interaction of the phosphorylated receptor with beta-arrestin. Little is known about other accessory endocytic proteins potentially involved. Here, we...
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