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Article

The distal and proximal regulatory regions of the involucrin gene promoter have distinct functions and are required for in vivo involucrin expression.

The Journal of investigative dermatology - 1 Feb 2006

Crish James F, Gopalakrishnan Ramamurthy, Bone Frederic, Gilliam Anita C, Eckert Richard L

Abstract excerpt

Involucrin is a marker of human keratinocyte differentiation. Previous studies show that the human involucrin gene promoter has two distinct regulatory regions - the proximal regulatory region (PRR) and the distal regulatory region (DRR). To study the role of these regions in vivo, we have constructed human involucrin promoter transgenic mice and monitored the impact of specific promoter mutations on involucrin...

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PMID: 16374477
DOI: 10.1038/sj.jid.5700019

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EBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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