Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involucrin expression in the corneal epithelium: an essential role for Sp1 transcription factors.

Investigative ophthalmology & visual science - 1 Sept 2005

Adhikary Gautam, Crish James F, Gopalakrishnan Ramamurthy, Bone Frederic, Eckert Richard L

Abstract excerpt

PURPOSE: Identifying the mechanism(s) that regulate gene expression during the transition of the limbal stem cell to a differentiated superficial cell is an important area of interest in the corneal epithelium. METHODS: However, the factors that regulate gene expression during this process are not well understood. In the present study, the human involucrin (hINV) gene was used as a model to study gene expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Electrophoretic Mobility Shift Assay
Share to Epithelium, Corneal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Mutagenesis, Site-Directed

Share to Protein Precursors

Share to Sp1 Transcription Factor

Share to Sp3 Transcription Factor

Share to Tetradecanoylphorbol Acetate

Source

Identifiers

PMID: 16123409
DOI: 10.1167/iovs.05-0053

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involucrin expression in the corneal epithelium: an essential role for Sp1 transcription factors.PMID 16123409Read ↗

The distal and proximal regulatory regions of the involucrin gene promoter have distinct functions and are required for in vivo involucrin expression.Semantic proximity Read ↗

The human involucrin gene contains spatially distinct regulatory elements that regulate expression during early versus late epidermal differentiation.Semantic proximity Read ↗

Down‐regulation of <i>Pax6</i> is associated with abnormal differentiation of corneal epithelial cells in severe ocular surface diseasesSemantic proximity Read ↗

Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in epidermal differentiation.Semantic proximity Read ↗

14-3-3σ controls corneal epithelium homeostasis and wound healing.Semantic proximity Read ↗

Essential role for Pbx1 in corneal morphogenesis.Semantic proximity Read ↗

Complex Interactions between Epidermal POU Domain and Activator Protein 1 Transcription Factors Regulate the Expression of the Profilaggrin Gene in Normal Human Epidermal KeratinocytesSemantic proximity Read ↗

The hSkn-1a POU transcription factor enhances epidermal stratification by promoting keratinocyte proliferation.Semantic proximity Read ↗

Spry1 and Spry2 are necessary for eyelid closure.Semantic proximity Read ↗

Interaction between GC Box Binding Factors and Smad Proteins Modulates Cell Lineage-specific α2(I) Collagen Gene TranscriptionSemantic proximity Read ↗

Laminin Reduces Expression of the Human α6 Integrin Subunit Gene by Altering the Level of the Transcription Factors Sp1 and Sp3Semantic proximity Read ↗

The human involucrin gene is transcriptionally repressed through a tissue-specific silencer element recognized by Oct-2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.