Article
An autoregulatory loop directs the tissue-specific expression of p63 through a long-range evolutionarily conserved enhancer.
Molecular and cellular biology - 1 Apr 2006
Antonini Dario, Rossi Barbara, Han Rong, Minichiello Annunziata, Di Palma Tina, Corrado Marcella, Banfi Sandro, Zannini Mariastella, Brissette Janice L, Missero Caterina
Abstract excerpt
p63, a p53 family member, is essential for the development of various stratified epithelia and is one of the earliest markers of many ectodermal structures, including the epidermis, oral mucosa, apical ectodermal ridge, and mammary gland. Genetic regulatory mechanisms controlling p63 spatial expression during development have not yet been defined. Using a genomic approach, we identified an evolutionarily...
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