Article
Tissue-specific and differentiation-appropriate expression of the human involucrin gene in transgenic mice: an abnormal epidermal phenotype.
Differentiation; research in biological diversity - 1 Jul 1993
Crish J F, Howard J M, Zaim T M, Murthy S, Eckert R L
Abstract excerpt
Involucrin is a precursor of the keratinocyte cornified envelope that is specifically expressed in the suprabasal layers of the epidermis and other stratifying squamous epithelia. To study involucrin gene expression and the function of involucrin, we expressed a 6 kb DNA fragment of the human inv...
Topics
- Alopecia
- Amino Acid Sequence
- Animals
- Animals, Newborn
- Cell Differentiation
- DNA, Complementary
- Disease Models, Animal
- Epidermis
- Female
- Gene Expression Regulation
- Genotype
- Hair
- Humans
- Keratinocytes
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic