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Article

CCAAT/enhancer-binding proteins. A role in regulation of human involucrin promoter response to phorbol ester.

The Journal of biological chemistry - 5 Mar 1999

Agarwal C, Efimova T, Welter J F, Crish J F, Eckert R L

Abstract excerpt

The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) is a potent inducer of keratinocyte differentiation and of involucrin gene expression. In the present study we show that a CCAAT/enhancer-binding protein (C/EBP) site in the proximal regulatory region is required for the phorbol ester response. Mutation of the C/EBP site results in the loss of basal and TPA-responsive activity. Gel mobility supershift...

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Source

Identifiers

PMID: 10037704
DOI: 10.1074/jbc.274.10.6190

Genes

EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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