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Article

The human involucrin gene contains spatially distinct regulatory elements that regulate expression during early versus late epidermal differentiation.

Oncogene - 24 Jan 2002

Crish James F, Bone Frederic, Banks Eric B, Eckert Richard L

Abstract excerpt

Human involucrin (hINV) is a keratinocyte protein that is expressed in the suprabasal compartment of the epidermis and other stratifying surface epithelia. Involucrin gene expression is initiated early in the differentiation process and is maintained until terminal cell death. The distal regulatory region (DRR) is a segment of the hINV promoter (nucleotides -2473/-1953) that accurately recapitulates the normal...

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Identifiers

PMID: 11850802
DOI: 10.1038/sj.onc.1205038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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The human involucrin gene contains spatially distinct regulatory elements that regulate expression during early versus late epidermal differentiation.PMID 11850802Read ↗

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