Article
Defining the Regulatory Factors Required for Epidermal Gene Expression
1 Apr 2000
Abstract excerpt
Keratins K5 and K14 are the hallmarks of mitotically active keratinocytes of stratified epithelia. They are transcribed at a high level and in a tissue-specific manner, enabling us to use the K14 gene to elucidate the regulatory mechanism underlying epidermis-specific transcription. We have identified four DNase I-hypersensitive sites (HSs) present in the 5' regulatory sequences of the K14 gene under specific...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.