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Article

A developmental timing microRNA and its target regulate life span in C. elegans.

Science (New York, N.Y.) - 23 Dec 2005

Boehm Michelle, Slack Frank

Abstract excerpt

The microRNA lin-4 and its target, the putative transcription factor lin-14, control the timing of larval development in Caenorhabditis elegans. Here, we report that lin-4 and lin-14 also regulate life span in the adult. Reducing the activity of lin-4 shortened life span and accelerated tissue aging, whereas overexpressing lin-4 or reducing the activity of lin-14 extended life span. Lifespan extension conferred...

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Identifiers

PMID: 16373574
DOI: 10.1126/science.1115596

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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A developmental timing microRNA and its target regulate life span in C. elegans.PMID 16373574Read ↗

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