Article
Lack of association between IBD5 and Crohn's disease in Japanese patients demonstrates population-specific differences in inflammatory bowel disease.
Scandinavian journal of gastroenterology - 1 Jan 2006
Tosa Masaki, Negoro Kenichi, Kinouchi Yoshitaka, Abe Hiroko, Nomura Eiki, Takagi Sho, Aihara Hiroyuki, Oomori Shinya, Sugimura Mikako, Takahashi Kazuma, Hiwatashi Nobuo, Takahashi Seiichi, Shimosegawa Tooru
Abstract excerpt
OBJECTIVE: Population-specific differences in the genetic susceptibility to inflammatory bowel disease (IBD) are indicated by the fact that Crohn's disease (CD) in Japanese patients does not have any of the common CARD15 variants that are associated with CD in Caucasians. Recently, the disease-causing mutation in the IBD5 haplotype was identified. The TC haplotype, composed of L503F in SLC22A4 and -207G/C in...
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