Article
A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease.
Gastroenterology - 1 Feb 2005
Newman Bill, Gu Xiangjun, Wintle Richard, Cescon David, Yazdanpanah Mehrdad, Liu Xiangdong, Peltekova Vanya, Van Oene Mark, Amos Christopher I, Siminovitch Katherine A
Abstract excerpt
BACKGROUND AND AIMS: Previously, we identified 2 functionally relevant polymorphisms in the SLC22A4 / 22A5 genes at the IBD5 locus that alter gene/protein function and comprise a 2-allele haplotype ( SLC22A -TC) associated with increased risk for Crohn's disease (CD). Here we examine the contribution of this susceptibility haplotype alone and in combination with CARD15 variants to CD subphenotypes and to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.