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Article

Analysis of the IBD5 locus and potential gene-gene interactions in Crohn's disease.

Gut - 1 Apr 2003

Negoro K, McGovern D P B, Kinouchi Y, Takahashi S, Lench N J, Shimosegawa T, Carey A, Cardon L R, Jewell D P, van Heel D A

Abstract excerpt

BACKGROUND AND AIMS: Genetic variation in the chromosome 5q31 cytokine cluster (IBD5 risk haplotype) has been associated with Crohn's disease (CD) in a Canadian population. We studied the IBD5 risk haplotype in both British and Japanese cohorts. Disease associations have also been reported for CARD15/NOD2 and TNF variants. Complex interactions between susceptibility loci have been shown in animal models, and we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12631666
DOI: 10.1136/gut.52.4.541
PMCID: PMC1773608

Genes

TNF
NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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