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Article

Deleterious and protective properties of an aggregate-prone protein with a polyalanine expansion.

Human molecular genetics - 1 Feb 2006

Berger Zdenek, Davies Janet E, Luo Shouqing, Pasco Matthieu Y, Majoul Irina, O'Kane Cahir J, Rubinsztein David C

Abstract excerpt

Many aggregate-prone proteins, including proteins with long polyglutamine or polyalanine tracts, cause human diseases. Polyalanine proteins may also be present in the tissue of polyglutamine diseases as a result of frameshifting of the primary polyglutamine-encoding (CAG)n repeat mutation. We have generated a Drosophila model expressing green fluorescent protein tagged to 37 alanines that manifests both toxicity...

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Identifiers

PMID: 16371423
DOI: 10.1093/hmg/ddi460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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