Article
Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila.
Human molecular genetics - 1 Jan 2000
Marsh J L, Walker H, Theisen H, Zhu Y Z, Fielder T, Purcell J, Thompson L M
Abstract excerpt
Several dominant, late-onset neurodegenerative diseases (e.g. Huntington's disease) are caused by expansion of polyglutamine (polyQ) repeats within specific proteins. The diverse, yet overlapping, pathology of these diseases could be due to novel deleterious functions unique to each protein or to a common pathophysiology mediated by the long polyQ chains themselves. By engineering Drosophila to express different...
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