Article
[Neurodegenerative conformational disease and heat shock proteins].
Yao xue xue bao = Acta pharmaceutica Sinica - 1 Nov 2010
Kong Xiang-Chen, Bao Xiu-Qi, Liu Geng-Tao
Abstract excerpt
Many major neurodegenerative diseases are associated with proteins misfolding and aggregation, which are also called "neurodegenerative conformational disease". The interaction of gene mutation and environmental factors are probably primary events resulting in oligomer and aggregate formations of proteins. Moreover, the dysfunctions of protein control systems, i.e. the ubiquitin-proteasome system and...
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