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Article

A yeast model for polyalanine-expansion aggregation and toxicity.

Molecular biology of the cell - 15 Jun 2011

Konopka Catherine A, Locke Melissa N, Gallagher Pamela S, Pham Ngan, Hart Michael P, Walker Claire J, Gitler Aaron D, Gardner Richard G

Abstract excerpt

Nine human disorders result from the toxic accumulation and aggregation of proteins with expansions in their endogenous polyalanine (polyA) tracts. Given the prevalence of polyA tracts in eukaryotic proteomes, we wanted to understand the generality of polyA-expansion cytotoxicity by using yeast as a model organism. In our initial case, we expanded the polyA tract within the native yeast poly(Adenine)-binding...

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Identifiers

PMID: 21508314
DOI: 10.1091/mbc.E11-01-0037
PMCID: PMC3113764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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