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Article

Schizosaccharomyces pombe RanGAP homolog, SpRna1, is required for centromeric silencing and chromosome segregation.

Molecular biology of the cell - 1 Nov 2004

Kusano Ayumi, Yoshioka Tomoko, Nishijima Hitoshi, Nishitani Hideo, Nishimoto Takeharu

Abstract excerpt

We isolated 11 independent temperature-sensitive (ts) mutants of Schizosaccharomyces pombe RanGAP, SpRna1 that have several amino acid changes in the conserved domains of RanGAP. Resulting Sprna1ts showed a strong defect in mitotic chromosome segregation, but did not in nucleocytoplasmic transport and microtubule formation. In addition to Sprna1+ and Spksp1+, the clr4+ (histone H3-K9 methyltransferase), the S....

Topics

Active Transport, Cell Nucleus
Cell Nucleus
Centromere
Chromosome Segregation
Cytoplasm
DNA Mutational Analysis
GTPase-Activating Proteins
Gene Silencing
Green Fluorescent Proteins
Heterochromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Histones

Microscopy, Fluorescence

Mitosis

Models, Biological

Models, Molecular

Mutation

Protein Structure, Tertiary

Schizosaccharomyces

Source

Open in PubMed Open full text

Identifiers

PMID: 15317843
DOI: 10.1091/mbc.e04-01-0067
PMCID: PMC524752

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Schizosaccharomyces pombe RanGAP homolog, SpRna1, is required for centromeric silencing and chromosome segregation.PMID 15317843Read ↗

Loss of RanGEF/Pim1 activity abolishes the orchestration of Ran-mediated mitotic cellular events in S. pombe.Semantic proximity Read ↗

A mutation in NPS1/STH1, an essential gene encoding a component of a novel chromatin-remodeling complex RSC, alters the chromatin structure of Saccharomyces cerevisiae centromeres.Semantic proximity Read ↗

Mutations in Ran system affected telomere silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Schizosaccharomyces pombe Ras1 effector, Scd1, interacts with Klp5 and Klp6 kinesins to mediate cytokinesis.Semantic proximity Read ↗

The Schizosaccharomyces pombe hst4(+) gene is a SIR2 homologue with silencing and centromeric functions.Semantic proximity Read ↗

The fission yeast ran GTPase is required for microtubule integrity.Semantic proximity Read ↗

Schizosaccharomyces pombe centromere protein Mis19 links Mis16 and Mis18 to recruit CENP-A through interacting with NMD factors and the SWI/SNF complex.Semantic proximity Read ↗

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Abundance of the RSC nucleosome-remodeling complex is important for the cells to tolerate DNA damage in Saccharomyces cerevisiae.Semantic proximity Read ↗

Sap1 promotes the association of the replication fork protection complex with chromatin and is involved in the replication checkpoint in Schizosaccharomyces pombe.Semantic proximity Read ↗

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