Article
Helicobacter pylori and gastric carcinogenesis.
Journal of gastroenterology - 1 Jan 2009
Hatakeyama Masanori
Abstract excerpt
Gastric carcinoma is the second leading cause of cancer-related deaths in the world, accounting for more than 700,000 deaths each year. Recent studies have revealed that infection with cagA-positive Helicobacter pylori plays an essential role in the development of gastric carcinoma. The cagA-encoded CagA protein is delivered into gastric epithelial cells via the bacterial type IV secretion system, where it...
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