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Uracil DNA Glycosylase Disruption Blocks Ig Gene Conversion and Induces Transition Mutations

1 Jan 2006

Abstract excerpt

Ig gene conversion is most likely initiated by activation-induced cytidine deaminase-mediated cytosine deamination. If the resulting uracils need to be further processed by uracil DNA glycosylase (UNG), UNG inactivation should block gene conversion and induce transition mutations. In this study, we report that this is indeed the phenotype in the B cell line DT40. Ig gene conversion is almost completely...

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Identifiers

PMID: 16365429
DOI: 10.4049/jimmunol.176.1.365

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Source receipt: pubmed, retrieved 7 Sept 2026.

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