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Article

DNA-dependent protein kinase inhibits AID-induced antibody gene conversion.

PLoS biology - 1 Apr 2007

Cook Adam J L, Raftery Joanna M, Lau K K Edwin, Jessup Andrew, Harris Reuben S, Takeda Shunichi, Jolly Christopher J

Abstract excerpt

Affinity maturation and class switching of antibodies requires activation-induced cytidine deaminase (AID)-dependent hypermutation of Ig V(D)J rearrangements and Ig S regions, respectively, in activated B cells. AID deaminates deoxycytidine bases in Ig genes, converting them into deoxyuridines. I...

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Source

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Identifiers

PMID: 17355182
DOI: 10.1371/journal.pbio.0050080
PMCID: PMC1820612

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17355182-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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