CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation.

doi:10.1371/journal.pone.0001152

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Article

CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation.

PloS one - 14 Nov 2007

Loffredo John T, Friedrich Thomas C, León Enrique J, Stephany Jason J, Rodrigues Denise S, Spencer Sean P, Bean Alex T, Beal Dominic R, Burwitz Benjamin J, Rudersdorf Richard A, Wallace Lyle T, Piaskowski Shari M, May Gemma E, Sidney John, Gostick Emma, Wilson Nancy A, Price David A, Kallas Esper G, Piontkivska Helen, Hughes Austin L, Sette Alessandro, Watkins David I

Abstract excerpt

BACKGROUND: It is generally accepted that CD8+ T cell responses play an important role in control of immunodeficiency virus replication. The association of HLA-B27 and -B57 with control of viremia supports this conclusion. However, specific correlates of viral control in individuals expressing these alleles have been difficult to define. We recently reported that transient in vivo CD8+ cell depletion in simian...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18000532
DOI: 10.1371/journal.pone.0001152
PMCID: PMC2062500

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